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Updated: Jun 4, 2025
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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
719
Pharmacological Strategies for Postdischarge Nausea and Vomiting: Evidence-based Review Update.
1Graduate Programs of Nurse Anesthesia, Texas Wesleyan University, Fort Worth, TX.
Summary
This systematic review found limited evidence for drugs preventing post-discharge nausea and vomiting (PDNV). Combination drug therapy may be more effective than single agents, but more research is needed.
Area of Science:
- Pharmacology
- Evidence-based medicine
- Clinical trial analysis
Background:
- Post-discharge nausea and vomiting (PDNV) is a common complication.
- Effective prophylactic strategies for PDNV are crucial for patient recovery.
Purpose of the Study:
- To evaluate the effectiveness of various pharmacological agents in preventing PDNV.
- To synthesize evidence from randomized controlled trials on PDNV prevention.
Main Methods:
- Systematic review of randomized controlled trials.
- Searched multiple databases including PubMed, CINAHL, Cochrane, and Google Scholar.
- Included quality appraisal using the Johns Hopkins Evidence-Based Practice Guide.
Main Results:
- Analyzed 8 randomized controlled trials with 1,441 patients.
- Efficacy of agents like dexamethasone, olanzapine, and ondansetron varied.
- Combination therapy showed greater efficacy than monotherapy for PDNV mitigation.
Conclusions:
- Limited evidence exists for pharmacological prevention of PDNV.
- Scarcity of large-scale trials hinders recommendations for prophylactic drug therapy.
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