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Siesta behavior and genetics interact to influence obesity risk.
María Rodríguez-Martín1,2, Diego Salmerón2,3,4, Hassan S Dashti5,6,7
1Department of Physiology, University of Murcia, Murcia, Spain.
Obesity (Silver Spring, Md.)
|December 23, 2024
Summary
Genetic predisposition to siesta influences its association with obesity. Individuals with a higher genetic propensity for siesta who nap have lower odds of obesity and better weight loss outcomes.
Area of Science:
- * Human genetics and lifestyle behaviors
- * Obesity research and weight management
Background:
- * The Mediterranean lifestyle traditionally includes siesta, but its health implications, particularly concerning obesity, remain debated.
- * Genetic factors may influence an individual's propensity for siesta behavior.
Purpose of the Study:
- * To investigate the interplay between obesity, siesta habits, and genetic predisposition to siesta in a Mediterranean population.
- * To explore the association between siesta, genetic propensity, and weight management outcomes.
Main Methods:
- * Utilized the Siesta-Polygenic Score (PGS) in the ONTIME study (n=1278).
- * Assessed siesta behavior, Mediterranean lifestyle, and obesity grade via questionnaires.
- * Employed logistic regression analyses to examine associations.
Main Results:
- * A significant genetic influence on siesta propensity was observed (OR=1.17, p=0.015).
- * Higher genetic propensity for siesta correlated with poorer dietary habits.
- * Among those with high genetic propensity, siesta takers had lower odds of obesity (p=0.038) and higher odds of weight-loss success (p=0.007).
Conclusions:
- * Genetic predisposition to siesta may modify the relationship between siesta behavior and health outcomes, including obesity.
- * Findings suggest a personalized approach to understanding siesta's role in health and weight management.
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