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Injectable hydrogels for treating skin injuries in diabetic animal models: a systematic review
Gustavo Oliva Amaral1, Giovanna do Espirito Santo1, Ingrid Regina Avanzi1
1Department of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020 Brazil.
Journal of Diabetes and Metabolic Disorders
|December 23, 2024
Summary
Injectable hydrogels show promise for treating chronic diabetic wounds by promoting tissue healing and reducing inflammation. Further clinical research is needed to confirm their effectiveness in patients.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Diabetes mellitus (DM) causes chronic hyperglycemia, a major factor in non-healing skin wounds.
- Hydrogels are emerging as advanced wound dressings that support tissue regeneration.
- Injectable hydrogels offer a minimally invasive approach for wound treatment.
Purpose of the Study:
- To systematically review studies on injectable hydrogels for diabetic skin wound healing.
- To evaluate the efficacy of various hydrogel origins in preclinical diabetic rat models.
- To assess the impact of hydrogels on wound closure, inflammation, and tissue regeneration.
Main Methods:
- Systematic review conducted in March 2023 using PubMed and Scopus databases.
- Adherence to PRISMA and SYRCLE guidelines for systematic reviews.
- Search terms included "hydrogels," "injectable," "in vivo," "diabetes mellitus," and "skin wound dressing."
Main Results:
- 12 studies were selected, analyzing injectable hydrogels' biocompatibility and bioactivity in diabetic wound models.
- Hydrogels demonstrated positive effects on wound closure, inflammation reduction, and collagen deposition.
- Increased neoangiogenesis markers and reduced inflammatory factors were observed in hydrogel-treated groups.
Conclusions:
- Injectable hydrogels represent a promising therapeutic strategy for diabetic skin wound healing.
- Observed biocompatibility and bioactivity support their use in promoting skin regeneration.
- Further clinical investigations are essential to validate the therapeutic potential of these hydrogels.
