[Research progress in polysaccharide-modified lipid nanoparticles for drug delivery]

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Lipid nanoparticles (LNPs) are promising drug delivery vehicles due to their biocompatibility, non-immunogenicity, and high drug loading capacity.
• Unmodified LNPs suffer from poor stability, susceptibility to hydrolysis, and rapid clearance, limiting their therapeutic efficacy.
• Various modifications, including peptide, antibody, ligand, nucleic acid aptamer, and polysaccharide modifications, have been explored to enhance LNP performance.

Purpose of the Study:

• To review the preparation methods and applications of polysaccharide-modified lipid nanoparticles.
• To highlight the advantages of polysaccharide modification for improving LNP characteristics.
• To provide a reference for future research and development in polysaccharide-modified LNPs for clinical translation.

Main Methods:

• Literature review focusing on polysaccharide modification strategies for lipid nanoparticles.
• Analysis of reported preparation techniques for polysaccharide-modified LNPs.
• Evaluation of studies detailing the applications and performance of these modified nanoparticles.

Main Results:

• Polysaccharide modification significantly improves LNP stability, biocompatibility, and targeting precision.
• Polysaccharide-modified LNPs demonstrate reduced toxicity compared to unmodified counterparts.
• These nanoparticles exhibit enhanced drug loading efficiency and controlled release properties.

Conclusions:

• Polysaccharide-modified lipid nanoparticles offer a superior drug delivery platform with enhanced therapeutic potential.
• Their improved characteristics make them highly suitable for various clinical applications.
• Further research into polysaccharide-modified LNPs is warranted to fully realize their clinical benefits.