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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Biomedical Metal-Organic Framework Materials: Perspectives and Challenges.

Alec Wang1, Madeline Walden2, Romy Ettlinger3

  • 1Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, Forckenbeckstrasse 55, 52074 Aachen, Germany.

Advanced Functional Materials
|December 27, 2024
PubMed
Summary

Metal-organic frameworks (MOFs) show promise in medicine for drug delivery and treating diseases due to their unique properties. Bridging the gap between lab research and clinical use requires addressing key challenges for these advanced materials.

Keywords:
biomedicinemetal-organic frameworksmetallotherapynanoparticlesporous materials

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Metal-organic frameworks (MOFs) possess high porosity, crystallinity, and diverse structures, making them attractive for biomedical applications.
  • Their hybrid organic/inorganic nature allows MOFs to encapsulate drugs, metals, and gases, and interact with biological systems.
  • MOFs demonstrate stability in physiological conditions and potential in regenerative medicine when combined with biomedical materials.

Purpose of the Study:

  • To outline the intrinsic features of MOFs relevant to biomedical applications.
  • To discuss the potential of MOFs in detoxification, drug/gas delivery, and combination therapies.
  • To critically examine the challenges hindering the clinical translation of MOFs.

Main Methods:

  • Review of intrinsic properties of MOFs.
  • Analysis of preclinical research examples in various medical indications.
  • Discussion of engineering strategies for MOF-based nanomaterials.
  • Critical evaluation of translational challenges.

Main Results:

  • MOFs exhibit versatile capabilities for biomedical applications, including drug delivery and therapy.
  • Preclinical studies show efficacy in treating cancer, microbial, and inflammatory diseases.
  • Integration with materials like stents shows promise in regenerative medicine.

Conclusions:

  • MOFs offer significant potential for diverse biomedical applications, from drug delivery to therapeutic platforms.
  • Overcoming the translational gap requires focused research on clinical viability and realistic development approaches.
  • Further investigation into MOF-containing nanomaterials is crucial for their successful clinical integration.