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Risk of glaucoma with bisphosphonate use in patients with osteoporosis: a case-control study
Bonnie He1, Mahyar Etminan2,3, Rami Darwich4
1Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada. bonnie.he@dal.ca.
Eye (London, England)
|December 28, 2024
Summary
Bisphosphonate (BP) users with osteoporosis face a higher risk of acute angle closure (AAC) compared to non-users. Risedronate, a specific BP, showed an increased likelihood of AAC development.
Area of Science:
- Ophthalmology
- Pharmacology
- Bone Metabolism
Background:
- Bisphosphonates (BPs) are primary treatments for osteoporosis.
- Previous case reports suggest a potential link between BPs and acute angle closure (AAC).
Purpose of the Study:
- To investigate the risk of AAC and open-angle glaucoma (OAG) associated with bisphosphonate use in osteoporosis patients.
- To address the lack of large-scale epidemiological data on BPs and glaucoma risk.
Main Methods:
- Retrospective cohort study with case-control analysis (2008-2018).
- Utilized the PharMetrics Plus Database (IQVIA) with over 150 million patient records.
- Included 208,111 osteoporosis patients, defining AAC and OAG by ICD-9/10 codes and BP prescription history.
Main Results:
- Bisphosphonate users demonstrated a higher likelihood of developing AAC (adjusted IRR = 1.78).
- Risedronate users had a significantly increased risk of AAC compared to users of other bisphosphonate formulations (adjusted IRRs = 2.12).
- No increased risk of OAG was observed with bisphosphonate use.
Conclusions:
- Osteoporosis patients using bisphosphonates exhibit an elevated risk of acute angle closure.
- Risedronate is associated with a greater likelihood of developing AAC compared to other bisphosphonates.
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