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Single-Stage Reconstruction of Large Scalp Surgical Defects With Exposed Bone Using Matriderm Flex and Full-Thickness

Pedro Gil-Pallares1,2,3, Manuel Almenara-Blasco1,2, Alba Navarro-Bielsa1,2,4

  • 1Department of Dermatology, Miguel Servet University Hospital, Zaragoza, Spain.

The Australasian Journal of Dermatology
|December 30, 2024
PubMed
Abstract

Keywords:
Matridermdermal matrixdermal regeneration templateexposed bonefull‐thickness skin graftsingle‐stage reconstruction

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...