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Association between COPD and CKD: a systematic review and meta-analysis.
Zexin Liu1, Zhimin Ma1, Chaowei Ding2
1Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Frontiers in Public Health
|December 31, 2024
Summary
Patients with chronic obstructive pulmonary disease (COPD) have a significantly increased risk of developing chronic kidney disease (CKD). Furthermore, CKD worsens outcomes for COPD patients, increasing mortality risk.
Area of Science:
- Pulmonary Medicine
- Nephrology
- Epidemiology
Background:
- Chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) are prevalent global health issues.
- A significant association between COPD and CKD is recognized, necessitating further investigation into their interrelationship and impact on patient outcomes.
Approach:
- A systematic review and meta-analysis was conducted, adhering to PRISMA guidelines.
- Searched PubMed, EMBASE, and Cochrane Library databases up to December 31, 2023.
- Included 23 studies to assess CKD risk in COPD patients and CKD's impact on COPD prognosis, utilizing Newcastle-Ottawa Scale for quality assessment and random/fixed effects models for meta-analysis.
Key Points:
- COPD patients face a significantly elevated risk of developing CKD (OR 1.54, 95% CI: 1.28-1.84).
- CKD substantially increases short-term mortality risk in acute exacerbations of COPD (AECOPD) (OR 1.53, 95% CI: 1.44-1.63).
- CKD also significantly elevates long-term mortality risk in COPD patients (OR 1.70, 95% CI: 1.35-2.15).
Conclusions:
- This meta-analysis confirms a significant link between COPD and CKD.
- CKD adversely affects the prognosis of COPD patients, highlighting its clinical importance.
- Findings offer crucial guidance for managing patients with comorbid COPD and CKD.
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