Two New Cardiac Glycosides From Streblus asper.

Area of Science:

• Natural Products Chemistry
• Pharmacology
• Microbiology

Background:

• Streblus asper Lour. is a plant source of bioactive compounds.
• Cardiac glycosides are a class of compounds with diverse biological activities.
• Investigating novel compounds for antimicrobial and antiviral properties is crucial.

Purpose of the Study:

• To isolate and characterize new cardiac glycosides from Streblus asper Lour.
• To evaluate the inhibitory effects of these compounds against porcine epidemic diarrhea virus (PEDV).
• To assess the antibacterial activity of the isolated compounds against pathogenic bacteria.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation via spectroscopic analysis (NMR, MS) and chemical methods.
• In vitro assays to determine antiviral (PEDV) and antibacterial activity.

Main Results:

• Two novel cardiac glycosides, strasperoside K (1) and L (2), were successfully isolated and identified.
• Five known cardiac glycoside analogs (3-7) were also isolated.
• The isolated compounds demonstrated varying degrees of inhibitory activity against PEDV and tested bacterial strains.

Conclusions:

• The study successfully identified new cardiac glycosides from Streblus asper Lour.
• The findings suggest potential therapeutic applications for these compounds in combating viral and bacterial infections.
• Further research is warranted to explore the mechanisms of action and optimize the efficacy of these natural products.