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Association Between Hypnotics, Accidents, and Injuries: A Study Based on the Adverse Drug Event Reporting Database in
Rintaro Sogawa1, Masakazu Hatano2, Fumi Nishimura3
1Department of Pharmacy, Saga University Hospital, Nabeshima, Japan; sogawari@cc.saga-u.ac.jp.
In Vivo (Athens, Greece)
|December 31, 2024
Summary
Hypnotic drug use can increase accident risks. However, dual orexin receptor antagonists (DORAs) appear less associated with these events, offering safer sleep aid options.
Area of Science:
- Pharmacovigilance
- Drug Safety
- Clinical Pharmacology
Background:
- Hypnotic drug use is linked to accidents and injuries.
- Limited data exists on this association after adjusting for confounding factors.
- This study investigates the relationship between hypnotic drug use and adverse events.
Purpose of the Study:
- To determine if hypnotic drug use is associated with accidents and injuries.
- To compare the risk of accidents and injuries across different classes of hypnotic medications.
- To provide evidence for safer hypnotic drug selection.
Main Methods:
- Analysis of 772,387 reports from the Japanese Adverse Event Reporting Database (September 2003–April 2004).
- Calculation of Reporting Odds Ratios (RORs) for accidents and injuries associated with hypnotic drugs.
- Multivariate analysis adjusting for age, sex, reporting year, and concomitant medications.
Main Results:
- 12,484 reports linked hypnotic drugs to accidents and injuries.
- Melatonin receptor agonists showed a decreased adjusted ROR (1.26).
- Dual orexin receptor antagonists (DORAs) showed a non-significant adjusted ROR (1.04), indicating a loss of signal for accidents and injuries.
Conclusions:
- The risk of accidents and injuries varies among hypnotic drugs.
- DORAs may be less frequently associated with accidents and injuries compared to other hypnotics.
- Findings aid in informed selection of hypnotic medications for patient safety.
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