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Aminoglycoside/Hexadecanoic Acid Complex Lamellar Core Nanoparticles
Ajay J Khopade1, Nitin Chitranshi2
1Sun Pharma Advanced Research Centre, Nima Compound, Tandalja, Vadodara 390020, Gujarat, India.
ACS Omega
|January 1, 2025
Summary
Tobramycin sulfate (TbS) and hexadecanoic acid (HdA) formed stable lamellosomes, nano-sized drug carriers. These novel nanocarriers demonstrate potential for controlled drug release and multidrug delivery applications.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Aminoglycosides like tobramycin sulfate (TbS) are crucial antibiotics.
- Developing effective drug delivery systems is essential for improving therapeutic outcomes.
- Nanoparticle formulations offer potential for enhanced drug stability and targeted delivery.
Purpose of the Study:
- To develop novel nanocarriers for tobramycin sulfate (TbS).
- To characterize the nanostructure and stability of the developed particles.
- To evaluate the potential of these nanocarriers for co-delivery of other drugs.
Main Methods:
- Complexation of tobramycin sulfate (TbS) with hexadecanoic acid (HdA) to form a lamellar nanostructure.
- Production of nanoparticles using poloxamer 188 as a dispersing agent.
- Characterization of particle size, ζ-potential, and stability under varying conditions (NaCl concentration, pH).
- Evaluation of dexamethasone loading and in vitro drug release.
Main Results:
- Formation of stable, agglomerate-free lamellosomes (90-450 nm) with a TbS/HdA lamellar core and poloxamer shell.
- Nanoparticles exhibited good stability in 0.2 mol/L NaCl but were sensitive to pH changes.
- Successful loading of dexamethasone (up to ~2% w/w) without crystallization.
- Significantly retarded release of the entrapped drug.
Conclusions:
- TbS/HdA lamellosomes represent a promising nanocarrier system for aminoglycosides.
- The developed lamellosomes can encapsulate additional drugs, indicating potential for multidrug cargo.
- Steric effects and ionic charge contribute to nanoparticle stabilization, offering tunable properties for drug delivery.
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