Total Syntheses of Indole Terpenoids (-)-Lyngbyatoxin, (-)-Teleocidin A2, and (-)-7-Geranylindolactam V
Jordan MacQueen1, Charles Wilber1, Syed Faiq1
1Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Abstract:
A regiodivergent palladium-catalyzed Suzuki-Miyaura reaction has been successfully implemented to synthesize (-)-lyngbyatoxin, (-)-teleocidin A2, and (-)-7-geranylindolactam V. This ligand-controlled cross-coupling strategy allowed for the direct preparation of these natural products from a single advanced synthetic intermediate, providing the shortest reported route to each compound. Subsequent in vitro studies in cancer cell lines were conducted to explore the chemotherapeutic applications of these natural products.
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