Related Experiment Video
Updated: Jun 14, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Understanding Noninferiority Trials: What Stroke Specialists Should Know
Fabiano Cavalcante1, Kilian M Treurniet1,2, Manon Kappelhof1
1Department of Radiology and Nuclear Medicine (F.C., K.M.T., M.K., C.B.M.), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Neuroscience, the Netherlands.
Abstract:
Noninferiority trials aim to prove that the efficacy, defined in terms of a key clinical outcome, of a new treatment is not meaningfully worse than that of an established active control. Noninferiority trials are important when other aspects of care can be improved, such as convenience, toxicity, costs, and safety (nonefficacy benefits). While the motivation for a noninferiority trial is straightforward, the design, execution, and interpretation of these trials is not a trivial task. Several safeguards that protect superiority trials from incorrect conclusions do not apply or even work in reverse for noninferiority trials. This review aims to provide stroke clinicians and researchers with a general overview of noninferiority trials and a deeper understanding of 10 pitfalls they should consider when designing and interpreting such trials.
More Related Videos
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
06:28E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Related Concept Videos
Goodness-of-Fit Test
Wald-Wolfowitz Runs Test I
The test works...
Significance Testing: Overview
Testing Water Quality
Non-destructive Tests for Concrete Strength
Friedman Two-way Analysis of Variance by Ranks