Related Experiment Video
Updated: May 7, 2025
07:29
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
10.7K
Adrenomedullin in pulmonary hypertension
Toshio Nishikimi1,2, Hideyuki Kinoshita1, Hideaki Inazumi1
1Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
Danish Medical Journal
|January 3, 2025
Summary
Adrenomedullin (AM) is a key factor in pulmonary hypertension, improving blood flow and preventing disease progression. This peptide shows promise as a therapeutic target for this serious cardiovascular condition.
Area of Science:
- Cardiovascular Research
- Pulmonary Medicine
- Endocrinology
Background:
- Adrenomedullin (AM) is known for its potent pulmonary vasodilatory effects, partly mediated by nitric oxide.
- Elevated plasma AM levels are observed in pulmonary hypertension patients, correlating with disease severity and adverse outcomes.
Purpose of the Study:
- To investigate the role of Adrenomedullin (AM) in the pathophysiology of pulmonary hypertension.
- To evaluate AM as a potential therapeutic target for pulmonary hypertension.
Main Methods:
- Review of existing literature on Adrenomedullin (AM) and pulmonary hypertension.
- Analysis of studies on AM administration in animal models and human patients with pulmonary hypertension.
Main Results:
- Acute AM administration improves hemodynamic parameters in pulmonary hypertension patients.
- Chronic AM administration in animal models prevents the development and progression of pulmonary hypertension.
Conclusions:
- Adrenomedullin (AM) plays a significant role in the development and progression of pulmonary hypertension.
- AM represents a promising therapeutic target for managing pulmonary hypertension due to its vasodilatory and protective effects.
Related Concept Videos
01:30Adrenergic Agonists: Therapeutic Uses
673
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
673
01:30Pulmonary Hypertension: Classification and Pathogenesis
102
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
102
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
82
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
82
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
299
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
299
01:18Adrenergic Agonists: Therapeutic Classification
610
Adrenergic agonists can be classified based on their therapeutic uses and mechanisms of action. They serve various purposes in clinical applications.
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
610
01:30Adrenergic Agonists: Direct-Acting Agents
1.2K
Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...
These agents can be classified...
1.2K