Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

305
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
305
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

295
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
295
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

5.6K
Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A lifespan pooled analysis of 832 cases: characterizing the lifespan profile of clinical presentations and comorbidities in congenital pulmonary airway malformation.

Orphanet journal of rare diseases·2026
Same author

Prognostic value of the triglyceride-glucose index combined with glycemic variability for all-cause mortality in patients with sepsis: A retrospective cohort study.

Science progress·2026
Same author

Hybrid SU(1,1) Interferometry in Optomechanics.

Physical review letters·2026
Same author

<i>In vivo</i> immune engineering via mRNA therapeutics: reprogramming the post-infarction cardiac microenvironment.

Frontiers in immunology·2026
Same author

Mitochondrial DNA-driven intercellular communication networks in post-infarction ventricular remodeling: the three-threshold model of cGAS-STING activation.

Frontiers in immunology·2026
Same author

Meta-operators: all optical and wireless image processing via metasurfaces.

Light, science & applications·2026
Same journal

Monolithic Axial InGaAs Quantum Dot Emitters in GaAs-Based Nanowires via Sb-Mediated Facet Engineering.

Nano letters·2026
Same journal

Electrical Imaging of DNA Substructures Using Quasi-Static Nanopore Scanning.

Nano letters·2026
Same journal

Structural Basis of Hemoglobin Amyloid Fibrils Revealed by cryo-EM and Molecular Dynamics Simulations.

Nano letters·2026
Same journal

Rashba-Related Spin-Selective Effect in 2D Chiral Perovskites with Achiral Organic Cation Spacers.

Nano letters·2026
Same journal

Visualizing Superconducting Gap Modulation Induced by Pair-Breaking Scattering Interference in Bulk FeSe.

Nano letters·2026
Same journal

Generalized Geometric Phase for Coupled Meta-Atoms.

Nano letters·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional &#960;-conjugate Systems
09:57

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems

Published on: February 10, 2020

7.1K

Fiber Vector Light-Field-Based Tip-Enhanced Raman Spectroscopy.

Chao Meng1, Zhonglin Xie1, Fanfan Lu1

  • 1Key Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, China.

Nano Letters
|January 3, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel fiber vector light-field technique for tip-enhanced Raman spectroscopy (TERS). This method enhances electric field gradients and optomagnetic fields, enabling the observation of Raman-forbidden transitions and strong plasmon coupling.

Keywords:
Raman forbidden transitionsStark effectfiber vector light fieldtip-enhanced Raman scattering

More Related Videos

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

1.8K
Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
09:57

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Published on: July 25, 2022

3.9K

Related Experiment Videos

Last Updated: Jun 4, 2025

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional &#960;-conjugate Systems
09:57

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems

Published on: February 10, 2020

7.1K
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

1.8K
Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
09:57

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Published on: July 25, 2022

3.9K

Area of Science:

  • Nanoscale Optics and Spectroscopy
  • Light-Matter Interactions
  • Molecular Physics

Background:

  • Tip-enhanced Raman spectroscopy (TERS) is crucial for nanoscale light-matter interaction studies.
  • Existing TERS methods struggle to simultaneously enhance electric fields, gradients, and optomagnetic fields.
  • A need exists for advanced TERS strategies to probe complex molecular responses.

Purpose of the Study:

  • To develop a fiber vector light-field-based TERS strategy.
  • To investigate multipole Raman scattering processes in molecules.
  • To overcome limitations of current TERS techniques in enhancing multiple electromagnetic fields.

Main Methods:

  • Utilized a fiber vector light-field excitation source.
  • Employed tip-enhanced Raman spectroscopy (TERS) with modulated excitation power.
  • Manipulated plasmon tip geometry to control nanogap size.

Main Results:

  • Observed the Stark effect in Raman-forbidden transitions for the first time.
  • Demonstrated significant electric-field gradient and optomagnetic effects within the plasmon cavity.
  • Observed dipole Raman spectrum splitting, indicating entry into a strong coupling regime.

Conclusions:

  • The developed TERS approach enables simultaneous enhancement of electric fields, gradients, and optomagnetic fields.
  • This method allows for the study of weak molecular responses, including Raman-forbidden transitions.
  • Potential applications include single-molecule spectroscopy, advanced sensors, and real-time catalysis monitoring.