Electrochemical Three-Component C-H Functionalization of Indoles with Sodium Bisulfite and Alcohols to Access
Wei Zhou1, Peng Chen1, Xiao-Qing Xie1
1Jiangxi Provincial Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China.
Abstract:
Herein, an efficient electrochemical three-component C-H functionalization of indoles with sodium bisulfite and alcohols is described, providing a sustainable and convenient synthetic route for the construction of structurally valuable indole-containing sulfonate esters in moderate to good yields. This protocol proceeds in an undivided cell without any metal catalysts or oxidants, features a broad substrate scope, and has an excellent functional group tolerance. Preliminary mechanistic studies suggest that a radical-radical pathway may be involved in this three-component reaction system.
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