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Diagnostic Performance and Safety of Ultrasound-Guided Core Needle Biopsy for Diagnosing Lymphoma: A Systematic
Yongmin Kwon1, Min Kyoung Lee1
1Department of Radiology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background:
Lymphoma arises from transformed lymphoid cells. Although surgical excision biopsy is the standard diagnostic tool for patients with lymphoma, image-guided fine-needle aspiration (FNA) or core needle biopsy (CNB) is considered an alternative diagnostic option.
Objective:
To assess the diagnostic accuracy and safety of ultrasound (US)-guided core needle biopsy (CNB) in patients with lymphoma.
Methods:
A systematic review and meta-analysis were conducted. A literature search was performed up to January 1, 2024, using the Ovid-MELIBE and EMBASE databases to identify studies focusing on US-guided CNB in lymphoma patients. Relevant outcomes, including sensitivity, specificity, and complication rates, were extracted from the included studies. The Der-Simonian-Laird random-effects model was applied to analyze the pooled data.
Results:
The pooled sensitivity of US-guided CNB in lymphoma patients was 94% (95% CI = 89%-96%), and the specificity was 100% (95% CI = 94%-100%). The pooled complication rate was 1% (95% CI = 0%-3%), with self-limiting complications being the most common.
Conclusion:
US-guided CNB demonstrated high diagnostic accuracy and low complication rates in patients with lymphoma, supporting its use as an alternative diagnostic tool.
