Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

327
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
327
Uterus and Cervix01:18

Uterus and Cervix

579
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
579
Fetal Circulation01:14

Fetal Circulation

608
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
608
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

49
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
49
Ultrasonography01:17

Ultrasonography

4.2K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
4.2K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

391
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
391

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The analgesic efficacy of intrathecal morphine compared to peripheral regional analgesia in total hip arthroplasty: A systematic review and meta-analysis.

European journal of anaesthesiology·2026
Same author

The usefulness of the intergluteal cleft as a possible anatomical landmark of the neuraxial midline in obstetrics: a prospective observational study.

European journal of anaesthesiology·2026
Same author

Inferior patient-reported outcomes after total knee arthroplasty for post-traumatic versus primary osteoarthritis: a registry study.

BMC musculoskeletal disorders·2026
Same author

Development of a Step-By-Step Clinical Decision Tool for Difficult Spinal Anesthetics: A Case Report of a Pregnant Patient With Achondroplasia, Previous Lumbar Fusion, and Class III Obesity.

A&A practice·2026
Same author

Long-Term Outcomes Following Anatomic Double-Bundle Versus Single-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Autograft: A Randomized Controlled Trial With an Average 14-Year Follow-Up.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Enhanced Recovery in Obstetrics.

Obstetrics and gynecology clinics of North America·2026
Same journal

Reimagining cardiac surgery-the emerging role of prehabilitation and risk optimization.

Best practice & research. Clinical anaesthesiology·2026
Same journal

Prehabilitation and enhanced recovery after cardiac surgery.

Best practice & research. Clinical anaesthesiology·2026
Same journal

The role of biomarkers in the preoperative evaluation of cardiac surgical patients - A narrative review.

Best practice & research. Clinical anaesthesiology·2026
Same journal

Magic in a bottle? A Focused review of factor concentrates for the intraoperative treatment of acquired coagulopathy - Fibrinogen concentrate, prothrombin complex concentrate, and recombinant activated factor VII.

Best practice & research. Clinical anaesthesiology·2025
Same journal

ESAs in perioperative anemia management: Who, what, how and why?

Best practice & research. Clinical anaesthesiology·2025
Same journal

Does patient blood management represent good value for money?

Best practice & research. Clinical anaesthesiology·2025
See all related articles

Related Experiment Video

Updated: May 7, 2025

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

16.4K

Uterotonics update.

Desire N Onwochei1, Neel Desai1, Lawrence C Tsen2

  • 1Department of Anaesthesia, Guy's & St. Thomas' NHS Foundation Trust, London, UK; King's College London, London, UK.

Best Practice & Research. Clinical Anaesthesiology
|January 7, 2025
PubMed
Summary
This summary is machine-generated.

Uterotonics are crucial for managing postpartum hemorrhage. Newer evidence suggests lower first-line uterotonic doses are effective, necessitating earlier consideration of second-line agents like ergometrine based on patient comorbidities.

Keywords:
CarbetocinOxytocinPostpartum haemorrhageUterotonics

More Related Videos

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.5K
Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

8.9K

Related Experiment Videos

Last Updated: May 7, 2025

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

16.4K
Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.5K
Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

8.9K

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Anesthesiology

Background:

  • Postpartum hemorrhage (PPH) management relies heavily on uterotonics.
  • Understanding uterotonic mechanisms and appropriate use is vital for obstetric anesthesiologists.
  • Oxytocin receptor desensitization impacts the efficacy of first-line uterotonics.

Purpose of the Study:

  • To review first- and second-line uterotonics for PPH management.
  • To detail their mechanisms of action, pharmacokinetics, side effects, and contraindications.
  • To provide evidence-based guidance on dosing and comparisons.

Main Methods:

  • Review of current literature on uterotonics for PPH.
  • Analysis of pharmacodynamic and pharmacokinetic properties.
  • Comparison of efficacy, safety, and contraindications of various uterotonics.

Main Results:

  • First-line uterotonics include oxytocin and carbetocin, with evidence supporting lower effective doses.
  • Second-line uterotonics (ergometrine, carboprost, sulprostone, misoprostol) may need earlier administration due to receptor desensitization.
  • Choice of second-line agent depends on patient comorbidities.

Conclusions:

  • Optimal PPH management requires a thorough understanding of all available uterotonics.
  • Earlier consideration of second-line uterotonics is supported by evidence of first-line agent desensitization.
  • Individualized patient factors are critical in selecting appropriate uterotonic therapy.