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The Possible Role of Plant-Based Bars Consumption in CKD Geriatric Patients
Giulia Marrone1, Silvia Urciuoli2, Manuela Di Lauro1
1Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
Summary
Plant-based bars improved body composition and cognitive function in geriatric patients with chronic kidney disease (CKD). The study also observed a reduction in oxidative stress (OS) in CKD patients consuming these bars.
Area of Science:
- Gerontology
- Nephrology
- Nutritional Science
Background:
- Geriatric patients with chronic kidney disease (CKD) exhibit accelerated aging due to uremic milieu, oxidative stress (OS), and microinflammation.
- These factors contribute to a pro-aging mechanism, increased protein catabolism, and cognitive disorders in CKD patients.
- CKD accelerates the aging process, impacting body composition and cognitive abilities.
Purpose of the Study:
- To assess the impact of consuming two types of plant-based bars (PBBs) on body composition, cognitive function, inflammation, and OS in geriatric CKD patients.
- This pilot study investigated potential health benefits of PBBs in an aging CKD population.
- Evaluating the efficacy of PBBs in mitigating age-related decline in CKD patients.
Main Methods:
- A 12-week pilot study involving 29 geriatric CKD patients (19 PBBs group, 10 control group).
- PBBs were moderately caloric and enriched with wine/olive oil by-products and organic saffron.
- Body composition assessed via bioimpedance and ultrasound; cognitive function by mini-mental state examination; OS by free oxygen radical test.
Main Results:
- The PBBs group demonstrated significant improvements in body composition compared to the control group.
- Cognitive function, assessed by mini-mental state examination, improved in the PBBs group.
- A reduction in oxidative stress (OS) was observed in the PBBs group.
Conclusions:
- Consumption of PBBs shows potential benefits for geriatric CKD patients, improving body composition and cognitive function.
- PBBs may help counteract premature aging and reduce oxidative stress in this population.
- Further research is warranted to confirm these findings and explore therapeutic applications.
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