Related Experiment Videos
Thiazide diuretic therapy and chronic photosensitivity
Archives of Dermatology
|April 1, 1985
Summary
Hydrochlorothiazide can cause long-lasting photosensitivity in some individuals, leading to severe sun reactions. This persistent sun sensitivity, even after discontinuing the drug, was effectively treated with methoxsalen and UV-A radiation.
Area of Science:
- Dermatology
- Photobiology
Background:
- Hydrochlorothiazide is a common diuretic.
- Photosensitivity reactions to medications can occur.
Observation:
- Four patients (44-66 years) developed chronic photosensitivity after hydrochlorothiazide ingestion.
- Photosensitivity persisted for months to years after drug cessation.
- Phototesting showed reduced minimal erythemal doses to UV-B and/or UV-A radiation.
Findings:
- Skin biopsies revealed acute eczematous dermatitis at test and lesional sites.
- All tested patients exhibited abnormal responses to UV radiation.
Implications:
- Hydrochlorothiazide can induce persistent photosensitivity.
- Methoxsalen and UV-A photochemotherapy offers a treatment option for this condition.