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Updated: Jun 3, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Defluorinative functionalization approach led by difluoromethyl anion chemistry

Kensuke Muta1,2, Kazuhiro Okamoto1, Hiroki Nakayama1

  • 1Department of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan.

Nature Communications
|January 8, 2025
PubMed
Summary

Researchers developed a flow chemistry method to convert trifluoromethyl groups into difluoromethyl motifs, addressing concerns about fluorinated compounds. This approach enables diverse functional group transformations for drug and agrochemical discovery.

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