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Longitudinal Associations Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Subclinical

Yanan Qiao¹, Lili Yang¹, Hui Yang¹

¹Department of Epidemiology/Department of Maternal, Child and Adolescent Health, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

The American Journal of Gastroenterology

|January 9, 2025

Abstract

Introduction:

The clinical utility of metabolic dysfunction-associated steatotic liver disease (MASLD) in predicting subsequent subclinical cardiovascular damages in pediatric population remains poorly understood.

Methods:

Data on 1,161 Chinese children aged 10-15 years were used to assess the longitudinal associations of MASLD with subsequent subclinical cardiovascular measures.

Results:

Compared with relatively healthy children, children with MASLD had abnormal vascular and cardiac structures, along with reduced cardiac diastolic function at the 2-year follow-up. In addition, children with MASLD had a significantly increased risk of high carotid intima-media thickness and left ventricular hypertrophy.

Discussion:

These findings support the clinical utility of MASLD in predicting the development of subclinical cardiovascular damages in childhood.

Keywords:

LVH MASLD chinese children high cIMT subclinical cardiovascular outcomes

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