Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

3.3K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
3.3K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.4K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.4K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
Antifungal Agents01:15

Antifungal Agents

131
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
131
Anthelminthic Agents01:15

Anthelminthic Agents

115
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
115

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of an intervention for a liquefied petroleum gas cook-stove with free fuel on food insecurity and dietary diversity among women and infants: a multi-country randomized controlled trial.

Food security·2026
Same author

Correction: A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.

Journal of cardiovascular translational research·2026
Same author

Pregnancy and Alzheimer's disease: Understanding maternal and neonatal neurological risks.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Curcumin-loaded nanocarriers for dermatological applications: current advances and biomedical implications.

EXCLI journal·2026
Same author

A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.

Journal of cardiovascular translational research·2026
Same author

Advances in Ciprofloxacin Derivatives: Emerging Strategies to Combat Antimicrobial Resistance.

Topics in current chemistry (Cham)·2026

Related Experiment Video

Updated: May 6, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.4K

Recent Developments in Azetidinone-Azole Conjugates: Emerging Antimicrobial Potentials.

Dinesh Kumar Mehta1, Rajiv Chaurasiya1, Rina Das1

  • 1Department of Pharmaceutical Chemistry, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India.

Medicinal Chemistry (Shariqah (United Arab Emirates))
|January 10, 2025
PubMed
Summary

Hybrid azetidinone-azole molecules show promise against drug-resistant microbes. This research explores their synthesis and potent antimicrobial activity, offering new hope for combating infectious diseases.

Keywords:
Azetidinoneantimicrobialsazolestetrazolesthiazoles.triazole

More Related Videos

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.6K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.5K

Related Experiment Videos

Last Updated: May 6, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.4K
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.6K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.5K

Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Microbiology

Background:

  • Multidrug-resistant microbial strains present a critical global health threat.
  • Azetidinones and azoles are known for their potent antimicrobial properties.
  • Combining these pharmacophores may yield novel agents to overcome resistance.

Purpose of the Study:

  • To synthesize and evaluate novel hybrid molecules merging azetidinone and azole structures.
  • To investigate the antimicrobial potential of these conjugates against various pathogens.
  • To understand structure-activity relationships for optimized drug design.

Main Methods:

  • Synthesis of azetidinone-azole conjugates using methods like click chemistry and multicomponent reactions.
  • Antimicrobial evaluation against a spectrum of bacteria, fungi, and protozoa.
  • Structure-activity relationship (SAR) studies to identify key structural features.

Main Results:

  • Several synthesized azetidinone-azole hybrids demonstrated significant antimicrobial activity.
  • Compounds were effective against both Gram-positive and Gram-negative bacteria.
  • Activity was also observed against clinically relevant fungal strains.

Conclusions:

  • Azetidinone-azole hybrids represent a promising strategy for developing new antimicrobial agents.
  • These compounds show potential to combat drug-resistant pathogens.
  • Further research and optimization can lead to effective treatments for infectious diseases.