Electrochemistry-enabled Ir-catalyzed C-H/N-N bond activation facilitates [3+2] annulation of phenidones with
LuLu Zhao1, Jianjing Yang1, Kelu Yan1
1Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China. jjyang@whu.edu.cn.
Abstract:
A mild and efficient [3+2] annulation of phenidones with propiolates has been developed to access N-substituted indole alkylamides, enabled by merging electrochemistry with iridium catalysis using an undivided cell at room temperature. The mechanistic studies have confirmed that the electrochemically mediated catalytic cycle of IrI-IrIII-IrV exhibits enhanced efficiency, mild reaction conditions, and unconventional selectivity.
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