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Activity determination of 177Lu using TDCR-Čerenkov method
Zihao Fan1, Haoran Liu1, Zhijie Yang1
1National Institute of Metrology, Beijing, 100029, China.
Summary
Accurate measurement of Lutetium-177 (177Lu) activity is vital for clinical applications. An extended TDCR-Čerenkov method achieved high accuracy (0.62% uncertainty) for 177Lu measurements, aligning well with liquid scintillation counting.
Area of Science:
- Nuclear medicine
- Radiochemistry
- Metrology
Background:
- Accurate activity measurement of radionuclides like Lutetium-177 (177Lu) is essential for effective clinical applications and instrument calibration.
- Existing methods require adaptation to ensure precision for specific isotopes used in therapy.
Purpose of the Study:
- To extend the TDCR-Čerenkov method for precise activity measurements of 177Lu solutions.
- To validate the accuracy of the extended method against established techniques.
Main Methods:
- The TDCR-Čerenkov method was adapted to account for both beta and gamma transitions specific to 177Lu.
- Measurements were performed on 177Lu solutions.
Main Results:
- The extended TDCR-Čerenkov method provided accurate activity measurements for 177Lu.
- The method achieved a low uncertainty of 0.62%.
Conclusions:
- The adapted TDCR-Čerenkov method is a reliable technique for measuring 177Lu activity.
- Results show excellent agreement with liquid scintillation counting, confirming the method's validity.
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