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Reaction of Donor-Acceptor α-Diazo Esters and N,N-Dimethylformamide/γ-Lactams To Generate α-Amino-α-aroylethanoates
Xiaonan Mu1,2, Yulong Niu1, Minhui Guan1
1Advanced Research Institute and Department of Pharmaceutical Sciences, Taizhou University, Taizhou, Zhejiang 318000, People's Republic of China.
Abstract:
Herein, we present a metal-free, concise, and efficient protocol for the intermolecular reaction of amides (lactams) with donor-acceptor α-diazo esters to afford the functionalized α-amino-α-aroylethanoates. N-Methyl-2-pyrrolidone (NMP) and N,N-dimethylformamide (DMF) are employed as both reagents and solvents, allowing for the incorporation of all units into the products. The reaction is processed by the ester group migration and compatible with a broad range of substrates up to 50 examples.
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