Related Experiment Video
Updated: Jun 2, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Serum resistin increases in gestational diabetes but does not differ among various trimesters
Tahmina Ferdousi1, Tania Tofail1, Sharmin Jahan1
1Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Background And Aims:
Resistin is inflammatory adipocytokine released from adipose and other tissue. It is thought that it is related to insulin resistance and pathogenesis of gestational diabetes mellitus (GDM). This study was aimed to determine the level of serum resistin in mothers with GDM and normal glucose tolerance (NGT) in all trimesters to see whether it differs among different trimesters as well as between GDM and NGT.
Materials And Methods:
This cross-sectional study included 81 pregnant women with GDM and 86 NGT after challenging three samples of 75 gm oral glucose tolerance test (OGTT) following WHO-2013 criteria. Resistin was measured from serum samples obtained in fasting state during OGTT. Resistin was measured by sandwich ELISA method.
Results:
Resistin level [13.2(9.85, 16.0) vs. 4.66(3.53, 5.96), median (IQR); p < 0.001] was significantly higher in GDM than NGT group. This was also observed for all the trimesters [1st p < 0.001; 2nd p < 0.001; and 3rd p < 0.001 respectively] between the two groups. However, resistin showed no significant difference (p = NS for all) within each group among the three trimesters. By binary logistic regression, resistin was observed as an independent predictor for GDM (p < 0.001). On the other hand, Receiver operating characteristics (ROC) curve analysis explored resistin (AUC = 0.856; p < 0.001) as a good predictor for GDM.
Conclusions:
Resistin is statistically and significantly higher in GDM than that of NGT group irrespective of gestational age. It does not differ among three trimesters within any of GDM or NGT mothers. Resistin is a good predictor for GDM.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Dipeptidyl Peptidase 4 Inhibitors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...

