Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities
Melford Chuka Egbujor1, Paolo Tucci2, Luciano Saso3
1Department of Chemistry, Federal University Otuoke, 562103, Bayelsa State, Nigeria.
Mini Reviews in Medicinal Chemistry
|January 15, 2025
Summary
Amino acids are superior precursors for synthesizing bioactive sulfonamides compared to amines. This approach offers advantages like chirality, green chemistry alignment, and diverse pharmacological activities, making it a key area in organic chemistry research.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
Background:
- Traditional sulfonamide synthesis often uses amine-sulfonyl chloride reactions.
- Recent research highlights amino acids as advantageous precursors over amines for sulfonamide synthesis.
Purpose of the Study:
- To review synthetic processes for amino acid-derived sulfonamides.
- To emphasize the significance of amino acids in sulfonamide synthesis.
- To discuss structure-activity relationships and pharmacological properties.
Main Methods:
- Nucleophilic attack of the amino group on activated sulfonyl species forms the sulfonamide linkage.
- Exploration of established, cutting-edge, and novel synthetic techniques.
Main Results:
- Amino acids offer benefits including biological relevance, chirality, and green chemistry compatibility.
- Amino acid-derived sulfonamides exhibit broad pharmacological activities (antibacterial, antiviral, anticancer, etc.).
Conclusions:
- Amino acids provide a versatile platform for creating tailored sulfonamides.
- The use of amino acids in sulfonamide synthesis aligns with green chemistry principles and offers economic viability.
Keywords:
Sulfonamide synthesisamino acidsanti-trypanosomanucleophilic attack.pharmacological activitiesreaction mechanismMore Related Videos
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