Robust and Regular Micronano Binary Texture on the Complex Curved Surface for Enhanced Reendothelialization and...

Area of Science:

• Biomaterials Science
• Surface Engineering
• Medical Device Development

Background:

• Blood-contacting medical devices often elicit adverse immune responses, leading to thrombosis and hyperblastosis.
• Creating effective antithrombotic and reendothelialization surfaces, especially on complex curved geometries, is a significant challenge.

Purpose of the Study:

• To develop and evaluate a robust micronano binary texture on titanium surfaces for enhanced hemocompatibility.
• To assess the antithrombotic and reendothelialization capabilities of the modified surface for vascular implants.

Main Methods:

• Fabrication of a micronano binary texture on titanium surfaces with controlled mechanical strength and wettability.
• Superhydrophilic modification of the textured surface.
• In vitro and in vivo investigations to evaluate protein/blood cell interactions, coagulation, and endothelialization.

Main Results:

• The superhydrophilic micronano binary textured surface significantly suppressed plasma protein and blood cell adhesion/activation, reducing thrombosis.
• The modified surface upregulated key genes for cell adhesion, growth factor synthesis, and cytoskeleton remodeling, accelerating endothelial layer formation.
• Enhanced re-endothelialization was observed compared to pure titanium and superhydrophobic surfaces.

Conclusions:

• Superhydrophilic micronano binary textured titanium surfaces demonstrate excellent hemocompatibility by inhibiting thrombosis.
• The surface promotes the integrity and viability of the endothelial cell layer, enhancing long-term anticoagulation performance.
• This strategy offers a promising approach for improving vascular implant functionality.