Related Experiment Video
Updated: Jun 15, 2026
Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
Published on: February 15, 2022
Immature Smooth Muscle Infiltration in Sporadic Lymphangioleiomyomatosis: A Case Study
Conner Stearns1, DesiRae Muirhead2,3, Brandon Rosell2,4
1University of South Dakota Sanford School of Medicine.
Lymphangioleiomyomatosis (LAM) is a rare lung disease affecting women, causing progressive damage. Diagnosis involves identifying lung cysts and smooth muscle cell invasion, with treatment based on disease severity.
Area of Science:
- Pulmonology
- Rare Diseases
- Genetics
Background:
- Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease.
- It primarily affects women of reproductive age, often associated with Tuberous Sclerosis Complex (TSC).
- Pathology involves abnormal smooth muscle cell proliferation in the lungs.
Observation:
- A 43-year-old female presented with chest pain and shortness of breath.
- Imaging revealed bilateral pulmonary cysts and a spontaneous pneumothorax.
- A lung biopsy confirmed the diagnosis of LAM.
Findings:
- LAM can occur sporadically, not exclusively with TSC.
- The patient's presentation included characteristic cystic lung changes and pneumothorax.
- Diagnosis was confirmed via histopathological examination of lung tissue.
Implications:
- Early diagnosis and intervention are crucial for managing LAM.
- Understanding the sporadic nature of LAM broadens diagnostic considerations.
- Treatment strategies should be tailored to individual lung function and disease extent.
More Related Videos
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
07:36Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
