Related Experiment Video
Updated: May 4, 2026
Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
Published on: March 14, 2013
Reference Ranges for Cerebral Oxygenation in Neonates During Immediate Transition After Birth: Differences Between
Nariae Baik-Schneditz1,2,3, Daniel Pfurtscheller1,2,3, Christina H Wolfsberger1,2,3
1Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Aim:
The aim was to define reference ranges for cerebral oxygen saturation (crSO2-ROOT) during immediate transition after birth in stable neonates.
Methods:
In a prospective observational study, the crSO2-ROOT was continuously measured in neonates during the first 15 min after birth. The neonatal sensor was placed on the head and fixed with a bandage. Median values and 10th and 90th centiles were calculated for each minute. Additionally, cerebral fractional tissue oxygen extraction (cFTOE-ROOT) was calculated using crSO2-ROOT and arterial oxygen saturation (SpO2) measured with pulse oximetry. These crSO-ROOT values were compared with already published reference ranges of cerebral oxygen saturation measured using different devices: crSO2-INVOS and cTOI-NIRO.
Results:
The data of 122 neonates (14 preterm/108 term neonates) were analysed. The crSO2-ROOT values had a similar course when compared to cTOI-NIRO values, whereas crSO2-INVOS values were initially lower and exceeded during the first minutes after birth.
Conclusion:
The present observational study added reference ranges of crSO2-ROOT in stable neonates immediately after birth. As there are differences regarding reference ranges of various near-infrared spectroscopy (NIRS) devices, it is important to be aware of this information for future clinical use.
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