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Choroidal thickness under pilocarpine versus cyclopentolate.

Mukharram M Bikbov1, Gyulli M Kazakbaeva1, Songhomitra Panda-Jonas2,3

  • 1Ufa Eye Research Institute of Bashkir State Medical University, 90 Pushkin Street, Ufa, 450077, Russia.

Scientific Reports
|January 17, 2025
PubMed
Summary

Cyclopentolate and pilocarpine eye drops did not significantly alter subfoveal choroidal thickness (SFCT) in healthy young adults. This study investigated the effect of ciliary muscle contraction on Bruch's membrane position and choroidal thickness.

Keywords:
333Axial elongationAxial myopiaChoroidal thicknessCiliary muscleMyopia

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Area of Science:

  • Ophthalmology
  • Retinal Research
  • Ocular Physiology

Background:

  • Bruch's membrane (BM) connects to the optic nerve head and ciliary muscle.
  • The ciliary muscle's contractile state may influence posterior BM position and subfoveal choroidal thickness (SFCT).

Purpose of the Study:

  • To assess if changes in ciliary muscle contractile state affect posterior BM position by measuring SFCT.
  • To determine the impact of cycloplegia (cyclopentolate) and miosis (pilocarpine) on choroidal thickness.

Main Methods:

  • Healthy young adults received cyclopentolate 1% in one eye and pilocarpine 1% in the other.
  • Subfoveal choroidal thickness (SFCT) and midperipheral choroidal thickness were measured using optical coherence tomography (OCT) at baseline and 30 minutes post-instillation.
  • Measurements were taken by three independent examiners.

Main Results:

  • Neither cyclopentolate nor pilocarpine administration resulted in statistically significant changes in SFCT.
  • Midperipheral choroidal thickness also showed no significant changes after eye drop instillation.
  • Inter-examiner variability was noted, but did not impact the overall non-significant findings.

Conclusions:

  • Pharmacological manipulation of ciliary muscle tone with cyclopentolate and pilocarpine does not significantly alter choroidal thickness in healthy young adults.
  • The connection between ciliary muscle contraction and posterior Bruch's membrane position, as reflected by SFCT, appears minimal in this population.
  • Further research may be needed to explore potential subtle effects or effects in different age groups or conditions.