Related Experiment Video

Updated: May 11, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
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The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

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Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis

Monica Margoni1,2,3, Loredana Storelli1, Elisabetta Pagani1

  • 1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Annals of Neurology
|January 18, 2025
PubMed

Insights

Subventricular zone (SVZ) microstructural changes occur early in pediatric multiple sclerosis (MS) and correlate with brain damage, but not clinical impairment. These findings highlight early disease-related alterations in the SVZ in pediatric MS patients.

Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • The subventricular zone (SVZ) is a critical neurogenic niche.
  • Aging impacts SVZ microstructure, affecting neurogenesis and brain health.
  • Pediatric-onset multiple sclerosis (MS) presents unique challenges in understanding disease progression.

Purpose of the Study:

  • To investigate age-related microstructural changes in the SVZ.
  • To examine the association between SVZ microstructure and clinical disability in pediatric MS.
  • To explore the relationship between SVZ alterations and brain structural damage in pediatric MS.

Main Methods:

  • 141 pediatric-onset MS patients and 233 healthy controls (HC) underwent 3.0T MRI.
  • Fractional anisotropy (FA) and mean diffusivity (MD) were measured in the SVZ and thalamus.
  • Analysis correlated microstructural metrics with clinical disability and brain lesion volume.

Main Results:

  • In healthy controls, SVZ microstructure changed with age, with distinct patterns for FA and MD.
  • Pediatric MS patients exhibited higher SVZ FA compared to pediatric HC, while adult patients showed no difference.
  • SVZ and thalamic microstructural abnormalities in MS patients correlated with white matter lesion volume and reduced brain volumes.

Conclusions:

  • SVZ microstructural changes are evident early in pediatric MS.
  • These early SVZ alterations are associated with brain structural damage.
  • SVZ microstructural changes in pediatric MS do not appear to correlate with clinical impairment.
Abstract

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