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Updated: May 11, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
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Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis.

Monica Margoni1,2,3, Loredana Storelli1, Elisabetta Pagani1

  • 1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Annals of Neurology
|January 18, 2025
PubMed
Summary
This summary is machine-generated.

Subventricular zone (SVZ) microstructural changes occur early in pediatric multiple sclerosis (MS) and correlate with brain damage, but not clinical impairment. These findings highlight early disease-related alterations in the SVZ in pediatric MS patients.

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Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • The subventricular zone (SVZ) is a critical neurogenic niche.
  • Aging impacts SVZ microstructure, affecting neurogenesis and brain health.
  • Pediatric-onset multiple sclerosis (MS) presents unique challenges in understanding disease progression.

Purpose of the Study:

  • To investigate age-related microstructural changes in the SVZ.
  • To examine the association between SVZ microstructure and clinical disability in pediatric MS.
  • To explore the relationship between SVZ alterations and brain structural damage in pediatric MS.

Main Methods:

  • 141 pediatric-onset MS patients and 233 healthy controls (HC) underwent 3.0T MRI.
  • Fractional anisotropy (FA) and mean diffusivity (MD) were measured in the SVZ and thalamus.
  • Analysis correlated microstructural metrics with clinical disability and brain lesion volume.

Main Results:

  • In healthy controls, SVZ microstructure changed with age, with distinct patterns for FA and MD.
  • Pediatric MS patients exhibited higher SVZ FA compared to pediatric HC, while adult patients showed no difference.
  • SVZ and thalamic microstructural abnormalities in MS patients correlated with white matter lesion volume and reduced brain volumes.

Conclusions:

  • SVZ microstructural changes are evident early in pediatric MS.
  • These early SVZ alterations are associated with brain structural damage.
  • SVZ microstructural changes in pediatric MS do not appear to correlate with clinical impairment.