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Updated: Jun 1, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
The Emerging Potential of Lead-212 Theranostics
Kristin A Plichta1, John M Buatti1
1Department of Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Abstract:
The field of theranostics uses radiopharmaceuticals to diagnose and treat disease, allowing for a personalized approach to treatment. Most theranostic therapies involve the use of beta-emitting radiopharmaceuticals. Because of their higher energies and decreased range, the use of alpha-emitting radiopharmaceuticals offers potential advantages over beta-emitting radiopharmaceuticals, including the potential for improved cell kill and decreased toxicity to normal tissues. This article focuses on the potential use of lead-212 as a theranostic treatment agent.
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