Related Experiment Video
Updated: Jul 9, 2026
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Reverse shock index multiplied by Glasgow coma scale (rSIG) to predict mortality in traumatic brain injury:
Gustavo Adolfo Vásquez-Tirado1, Edinson Dante Meregildo-Rodríguez2, Claudia Vanessa Quispe-Castañeda3
1Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Peru; Unidad de Cuidados Intensivos, Hospital Regional Docente de Trujillo, Trujillo, Peru.
Objective:
To determine whether the Reverse Shock Index multiplied by the Glasgow Coma Scale (rSIG) is a predictor of in-hospital mortality in patients with traumatic brain injury (TBI).
Design:
This is a systematic review and meta-analysis.
Setting:
A comprehensive search was conducted in five databases for studies published up to May 22, 2024, using a PECO strategy. Eight studies were identified for quantitative analysis and included in our meta-analysis.
Participants:
The participants of the included primary studies.
Interventions:
Patients with a low rSIG as a predictor of in-hospital mortality in TBI.
Main Variables Of Interest:
rSIG, in-hospital mortality, TBI.
Results:
Our meta-analysis evaluated a total of eight observational studies encompassing 430,000 patients with TBI, observing 6,417 deaths (15%). After performing a sensitivity analysis, we found that patients with TBI and a low value of the reverse shock index multiplied by the Glasgow Coma Scale (rSIG) had a 24% higher risk of death (OR 1.24; 95% CI 1.12-1.38; I²: 96%). Furthermore, rSIG values were significantly higher in survivors compared to those who died (MD 7.72; 95% CI 1.86-13.58; I²: 99%).
