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Cancer therapy and reproductive impact
Dov Feldberg1,2, Nikhil Purandare3
1Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tivka, Israel.
Summary
Patients undergoing cancer treatments with potential harm to reproductive organs should seek oncofertility advice. Ovarian tissue cryopreservation is the primary urgent fertility preservation method for prepubertal girls, while testicular tissue preservation remains experimental.
Area of Science:
- Reproductive medicine
- Oncology
- Oncofertility
Background:
- Cancer therapies like chemotherapy and radiotherapy can severely impact ovarian function, leading to premature ovarian failure.
- Fertility preservation options are crucial for cancer patients desiring future biological children.
Purpose of the Study:
- To highlight the necessity of oncofertility consultations for all patients at risk of gonadotoxicity.
- To outline fertility preservation strategies based on patient age and clinical context.
Main Methods:
- Review of current oncofertility practices and their efficacy.
- Analysis of contraindications and limitations for fertility cryopreservation.
Main Results:
- Referral for oncofertility advice is recommended for all patients with cancer treatments having gonadotoxic potential.
- Ovarian tissue cryopreservation is the sole urgent fertility preservation option for prepubertal girls.
- Testicular tissue cryopreservation is currently considered experimental.
Conclusions:
- Oncofertility counseling is essential for informed decision-making regarding fertility preservation in cancer patients.
- Ovarian tissue cryopreservation offers a viable urgent fertility preservation solution for prepubertal females.
- Further research is needed to establish the efficacy of prepubertal testicular tissue cryopreservation.
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