Insights and Interventions in Age-Associated Inflammation.
Haoyan Huang1, Jie Ren2, Guang-Hui Liu3
1National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Current Opinion in Genetics & Development
|January 21, 2025
Summary
Aging accelerates due to chronic inflammation, a complex process driven by various factors. Understanding these drivers and developing anti-inflammatory strategies can mitigate aging and improve healthspan.
Area of Science:
- Gerontology and immunology
- Molecular and cellular biology
- Chronic disease research
Background:
- Aging is a complex, systemic process involving progressive physiological decline.
- Chronic inflammation, or 'inflammaging,' is a key hallmark and driver of aging.
- Inflammaging stems from diverse stimuli including pathogens, cellular damage, metabolic issues, and stress.
Purpose of the Study:
- To review recent mechanistic insights into age-related chronic inflammation.
- To explore potential anti-inflammatory interventions for mitigating aging.
- To identify challenges and future research directions in aging and inflammation.
Main Methods:
- Literature review of mechanistic studies on inflammaging.
- Analysis of emerging anti-inflammatory strategies targeting aging.
- Discussion of current challenges and future translational research.
Main Results:
- Mechanistic drivers of age-related chronic inflammation are increasingly understood.
- Several anti-inflammatory approaches show promise for mitigating aging.
- Significant challenges remain in translating findings into clinical practice.
Conclusions:
- Targeting chronic inflammation is a promising avenue for healthy aging interventions.
- Further research is needed to overcome translational hurdles.
- Interdisciplinary collaboration is crucial for advancing the field of aging research.
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