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Interest in Injectable and Oral PrEP for HIV Prevention Among Women and Men Who Inject Drugs
Elenore P Bhatraju1, Judith I Tsui, Moonseong Heo
1Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA (EPB, JIT); Department of Public Health Sciences, Clemson University, Clemson, SC (MH, SSL); School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada (LBS); Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (SM); Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA (PL); Department of Pharmacy Practice and Clinical Research, University of Rhode Island, Kingston, RI (LET); West Virginia University School of Medicine, Morgantown, WV (JF); Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA (AK); Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY (BN); Department of Psychology, Clemson University, Clemson, SC (IP-V); University of New Mexico Health Sciences Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM (KP); and Department of Medicine, University of South Carolina School of Medicine, Greenville, SC (AHL).
Injectable pre-exposure prophylaxis (PrEP) shows high interest among people who inject drugs (PWID), especially women. Key concerns include side effects and drug interactions, highlighting potential for improved HIV prevention strategies.
Area of Science:
- Public Health
- Infectious Disease Prevention
- HIV/AIDS Research
Background:
- People who inject drugs (PWID) face elevated human immunodeficiency virus (HIV) risk.
- Women who inject drugs represent a particularly vulnerable demographic.
- Pre-exposure prophylaxis (PrEP) is effective but faces access and uptake challenges.
Purpose of the Study:
- To evaluate interest and concerns regarding oral and injectable PrEP among PWID.
- To assess these attitudes based on gender.
Main Methods:
- Cross-sectional analysis of survey data from 284 participants across 8 US sites.
- Assessed demographics, HIV risk behaviors, and PrEP attitudes.
- Data analyzed overall and stratified by self-identified gender (female vs. male).
Main Results:
- Interest in injectable PrEP (49.5%) significantly exceeded interest in daily oral PrEP (20.1%).
- Top concerns cited were medication side effects (53%) and interactions (39.2%).
- Perceived HIV risk and PrEP concerns did not differ significantly between genders.
Conclusions:
- Injectable PrEP demonstrates high interest and potential acceptability among PWID.
- Addressing concerns about side effects and interactions is crucial for implementation.
- Further research should explore female participant advantages and optimize access strategies.
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