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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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MicroRNA-155 as Biomarker and Its Diagnostic Value in Breast Cancer: A Systematic Review
Bann Siang Yeo1, Wen Xuan Lee1, Rozi Mahmud2
1Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
World Journal of Oncology
|January 24, 2025
Summary
This review explores microRNAs (miRNAs), specifically miR-155, as potential diagnostic biomarkers for breast cancer. While miR-155 shows promise, further clinical research is needed to confirm its diagnostic accuracy and clinical utility.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are increasingly investigated as biomarkers and therapeutic targets for breast cancer.
- miR-155 is implicated in breast cancer development, regulating key cellular processes like proliferation and metastasis.
- Previous studies on miR-155 as a breast cancer biomarker have yielded varied results.
Purpose of the Study:
- To systematically review and synthesize existing data on miR-155 as a potential diagnostic biomarker for breast cancer.
- To evaluate the diagnostic performance of miR-155 across various biological samples.
- To correlate miR-155 expression with breast cancer clinicopathological features.
Main Methods:
- Systematic literature search of SCOPUS and PubMed databases.
- Inclusion and exclusion criteria applied to 376 records, selecting 26 original articles.
- Analysis of miR-155 expression in serum, plasma, biopsy, urine, nipple aspirate fluid, serum exosomes, and peripheral blood mononuclear cells.
- Receiver operating characteristic (ROC) analysis to assess diagnostic sensitivity and specificity (Area Under the Curve - AUC).
Main Results:
- miR-155 expression was analyzed in diverse sample types.
- Correlation between miR-155 expression and clinicopathological features was examined.
- AUC values were recorded to evaluate diagnostic potential.
Conclusions:
- miR-155 demonstrates potential as a diagnostic biomarker for breast cancer.
- Limitations include small sample sizes, inconsistent RT-qPCR controls, and variable sensitivity/specificity.
- Further clinical validation is essential for translating miR-155 research into clinical practice.
