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Updated: May 31, 2025
08:55
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
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Rings of death: How NINJ1 executes plasma membrane rupture
1MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Cell
|January 24, 2025
Summary
Plasma membrane rupture in cell death is an active process, not passive osmosis. Ninjurin-1 (NINJ1) oligomers mediate this rupture by dissolving membranes or forming large pores.
Area of Science:
- Cell biology
- Molecular biology
- Biochemistry
Background:
- Lytic cell death involves plasma membrane rupture.
- Previously, this rupture was thought to be a passive osmotic event.
Purpose of the Study:
- To investigate the mechanism of plasma membrane rupture during lytic cell death.
- To determine if plasma membrane rupture is an active or passive process.
Main Methods:
- Analysis of recent publications on cell death mechanisms.
- Investigation of the role of ninjurin-1 (NINJ1) in plasma membrane rupture.
Main Results:
- Plasma membrane rupture is an active process.
- Ninjurin-1 (NINJ1) oligomers mediate plasma membrane rupture.
- NINJ1 oligomers may dissolve membranes or form large pores.
Conclusions:
- The understanding of lytic cell death mechanisms has been updated.
- Ninjurin-1 (NINJ1) is a key mediator of plasma membrane rupture in active cell death processes.
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