Nanoparticle-Based Therapies for Management of Subarachnoid Hemorrhage, Neurotrauma, and Stroke

Neurotrauma, stroke, and subarachnoid hemorrhage (SAH) are symptomatically diverse and etiologically complex central nervous system pathologies. Despite numerous therapeutic modalities that are available to minimize neurologic damage and secondary injury, the prognosis can still be dismal and unpredictable. Nanoparticle (NP) technology allows for deliberate, modular, and minimally invasive drug delivery. This literature review encompasses pertinent information on the impact and versatility of nanoparticle therapeutics when treating neurotrauma, stroke, and SAH. Currently, notable treatments such as Perfluorooctyl-Bromide (PFOB), PLGA nanoparticles, and ischemic relief-based NPs are promising new techniques for the management of these complex pathologies.