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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population.

Hery Priyanto1, Fauqa Arinil Aulia2, Hartono Kahar2

  • 1Clinical Pathology Sub-Specialization Program, Department of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, Indonesia.

Children (Basel, Switzerland)
|January 25, 2025
PubMed
Summary
This summary is machine-generated.

This study establishes crucial thyroid-stimulating hormone (TSH) reference intervals for Indonesian neonates, considering age, sex, and ethnicity. These findings are vital for accurate neonatal screening and diagnosis in the local population.

Keywords:
child healthdry blood spotreference intervalsthyroid stimulating hormone

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Area of Science:

  • Neonatal screening and diagnostics
  • Endocrinology
  • Public health

Background:

  • Accurate thyroid-stimulating hormone (TSH) reference intervals are essential for neonatal health.
  • Existing TSH reference intervals may not accurately reflect diverse global populations, including Indonesians.
  • This study addresses the need for localized TSH reference ranges in Indonesia.

Purpose of the Study:

  • To establish precise thyroid-stimulating hormone (TSH) reference intervals for Indonesian neonates.
  • To tailor these intervals based on neonatal age groups, sex, gestational age, and ethnic background.
  • To improve the accuracy of neonatal screening and diagnosis within Indonesia.

Main Methods:

  • Utilized dried blood spot neonatal TSH values collected between January 2022 and December 2023.
  • Established TSH reference intervals by partitioning data according to sex, gestational age, and ethnic group.
  • Analyzed TSH values across various neonatal age subgroups.

Main Results:

  • Significant differences in TSH reference intervals were observed across sex, gestational age, and ethnic groups (p < 0.05).
  • Male neonates exhibited higher TSH reference intervals compared to females.
  • Higher TSH reference intervals were noted in late and post-term gestational age categories.
  • The Madurese ethnic group showed a higher upper limit for TSH reference intervals.

Conclusions:

  • Developed a localized set of TSH reference intervals specifically for the Indonesian neonatal population.
  • These tailored intervals are crucial for enhancing the diagnostic accuracy of neonatal screening in Indonesia.
  • The findings underscore the importance of considering demographic factors in establishing clinical reference ranges.