Films Based on Chitosan/Konjac Glucomannan Blend Containing Resveratrol for Potential Skin Application.

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Dermatology

Background:

• Biopolymers offer promising applications in skincare due to their inherent beneficial properties.
• Resveratrol, a natural compound, possesses significant antioxidant, anti-inflammatory, and anti-aging activities.
• Enriching biomaterials with active ingredients like resveratrol is a strategy to enhance final product efficacy.

Purpose of the Study:

• To prepare and characterize chitosan/konjac glucomannan thin films enriched with resveratrol.
• To evaluate the physical, mechanical, and antioxidant properties of these resveratrol-loaded films.
• To assess the release profile of resveratrol from the films under simulated skin conditions.

Main Methods:

• Preparation of resveratrol-enriched chitosan/konjac glucomannan films.
• Characterization using infrared spectroscopy, SEM, and AFM.
• Swelling, mechanical, and antioxidant assays.
• Contact angle measurements and resveratrol release studies.

Main Results:

• Resveratrol incorporation altered film's chemical structure and morphology.
• Films containing 10% resveratrol showed increased swelling.
• Resveratrol-modified films exhibited enhanced antioxidant capacity, reduced contact angle, and improved wettability.
• Rapid initial release of resveratrol was observed, up to 84% or 56% depending on the formulation.

Conclusions:

• The developed resveratrol-enriched biopolymer films possess promising properties for skincare applications.
• Key advantageous characteristics include good swelling capacity, high antioxidant potential, and improved wettability.
• These formulations may serve as effective skin dressings pending further investigation.