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Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation
Ha Vy Thi Vo1, Namdoo Kim2, Hyuck Jin Lee1
1Department of Chemistry Education, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of Korea.
Frontiers in Bioscience (Landmark Edition)
|January 25, 2025
Summary
Vitamin Bs regulate metalloenzymes crucial for cancer cell processes like DNA repair and signaling. This interaction offers potential for developing novel, targeted cancer therapies.
Area of Science:
- Biochemistry
- Oncology
- Nutritional Science
Background:
- Metalloenzymes are vital for cellular processes including DNA repair, cell signaling, and metabolism.
- These enzymes are increasingly recognized as key targets in cancer therapy.
- Coenzymes, particularly vitamin Bs, are essential nutrients with emerging roles in modulating enzyme activity.
Purpose of the Study:
- To review the intricate relationship between vitamin Bs and metalloenzymes in cancer.
- To explore the potential of targeting these interactions for cancer treatment.
- To summarize current knowledge on vitamin B-metalloenzyme interplay in cancer pathogenesis.
Main Methods:
- Literature review focusing on studies investigating vitamin B coenzymes and metalloenzymes in cancer.
- Analysis of research on the mechanisms of vitamin B-mediated enzyme modulation.
- Synthesis of findings related to cancer development, progression, and therapeutic strategies.
Main Results:
- Vitamin Bs significantly influence the activity and expression of metalloenzymes.
- This modulation affects critical cancer-related pathways such as DNA repair and cell signaling.
- Evidence suggests vitamin Bs can impact cancer progression through these mechanisms.
Conclusions:
- The interplay between vitamin Bs and metalloenzymes presents a promising avenue for novel anticancer strategies.
- Understanding these interactions can lead to the development of innovative, cell-targeted cancer treatments.
- Vitamin Bs hold potential as therapeutic agents in oncology.
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