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Updated: Jun 6, 2025

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
Published on: November 30, 2018
Regulating Histone Deacetylases and Carbonic Anhydrases by Metal Complexes: A Potent Strategy for Treating Cancers
Yen Thi Nguyen1, Namdoo Kim1, Hyuck Jin Lee2
1Department of Chemistry, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of Korea.
Abstract:
Utilizing metal complexes to inhibit histone deacetylases (HDACs) and carbonic anhydrases (CAs) highlights their therapeutic potential, particularly in anticancer strategies. The metal complexes, with their unique three-dimensional structures, fit adequately into the active sites of the enzymes, not only improving selectivity but also providing facile coordination with amino acid residues to enhance their inhibitory ability. This review emphasizes the role of metal complexes in the selective inhibition of HDACs and CAs along with details of their mechanism of action. Additionally, we summarize the inhibition ability and cytotoxicity of metal complexes targeting HDACs and CAs, as well as the therapeutic implications that can lead to the invention and development of metal complexes as potent anticancer agents.
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