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Updated: Jun 21, 2026
10:02
Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells
Published on: December 12, 2014
12.1K
[N-Acetylcysteine (NAC) for Retinitis pigmentosa]
Kristina Pfau1,2, Josep Callizo1, Petra Rossouw1
1Augenklinik, Universitätsspital Basel, Schweiz.
Klinische Monatsblatter Fur Augenheilkunde
|January 26, 2025
Summary
N-acetylcysteine (NAC) may slow vision loss in retinitis pigmentosa (RP) by reducing oxidative stress. This ongoing trial investigates NAC
Area of Science:
- Ophthalmology
- Neuroscience
- Genetics
Background:
- Retinitis pigmentosa (RP) is an inherited retinal disease causing progressive vision loss and blindness.
- Oxidative stress is a key factor in the pathogenesis of RP.
- N-acetylcysteine (NAC), an antioxidant, shows neuroprotective potential in preclinical RP models.
Purpose of the Study:
- To evaluate the efficacy and safety of N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP).
- To assess the impact of NAC on disease progression and visual function in RP.
Main Methods:
- A multicentre Phase III clinical trial named "NAC Attack" is underway.
- The study involves RP patients receiving NAC therapy.
- Long-term efficacy and safety of NAC are being evaluated.
Main Results:
- Initial studies suggest NAC therapy may improve visual acuity and macular function in RP patients.
- No structural retinal changes have been demonstrated in preliminary investigations.
- Further data from the Phase III trial are required for definitive conclusions.
Conclusions:
- NAC is a promising therapeutic candidate for retinitis pigmentosa due to its antioxidant properties.
- The "NAC Attack" trial will provide crucial data on NAC's long-term benefits for RP patients.
- Further research is needed to confirm structural benefits and optimal treatment protocols.
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