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RETROSPECTIVE OBSERVATIONAL STUDY OF VITAMIN D STATUS IN NEUROLOGICAL PATIENTS
Lucija Zadro Matovina1,2, Helena Trputac1, Antonia Nicinger3
1Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Acta Clinica Croatica
|January 27, 2025
Summary
Neurological patients show high rates of vitamin D insufficiency, though slightly lower than the general Croatian population. Supplementation and autoimmune disease diagnosis significantly impact vitamin D levels.
Area of Science:
- Neurology
- Endocrinology
- Public Health
Background:
- Vitamin D deficiency is a growing global health concern.
- Neurological conditions may be linked to altered vitamin D metabolism.
- Understanding vitamin D status in neurological patients is crucial for management.
Purpose of the Study:
- To determine the prevalence of vitamin D insufficiency in Croatian neurological patients.
- To compare this prevalence with the general Croatian population.
- To explore factors influencing vitamin D insufficiency in this cohort, including supplementation and autoimmune disease.
Main Methods:
- Retrospective analysis of 371 neurological patients over one year.
- Data collected: demographics, neurological diagnosis, serum 25-hydroxyvitamin D levels, and vitamin D3 supplementation history.
- Statistical comparison of vitamin D insufficiency rates across subgroups.
Main Results:
- 74.66% of neurological patients exhibited vitamin D insufficiency (<75 nmol/L).
- This prevalence was slightly lower than in the general Croatian population.
- Vitamin D insufficiency varied significantly based on vitamin D3 supplementation and autoimmune disease diagnosis, but not gender, season, or region.
Conclusions:
- A high proportion of neurological patients suffer from vitamin D insufficiency.
- Vitamin D supplementation and the presence of autoimmune diseases are key factors influencing vitamin D status in these patients.
- Further research into targeted vitamin D interventions for neurological patients is warranted.
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