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Related Experiment Video

Updated: May 30, 2025

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Skeletal organoids.

Chen Zhang^1,2,3, Yingying Jing^1,2, Jianhua Wang⁴

¹Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China.

Biomaterials Translational

|January 28, 2025

Summary

This summary is machine-generated.

Skeletal organoids offer a promising 3D model for studying bone, muscle, and joint diseases. This review explores their potential in regenerative medicine, addressing limitations of current treatments for skeletal disorders.

Keywords:

applications construction strategies organoids skeletal system

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Area of Science:

Biotechnology
Regenerative Medicine
Skeletal Biology

Background:

The skeletal system is crucial for posture and mobility, but aging and injury lead to prevalent disorders like osteoarthritis and muscle atrophy.
Current treatments for skeletal conditions are often ineffective, leading to pain, functional loss, and significant socioeconomic burdens.
There is a critical need for advanced therapeutic and reparative strategies to address limitations in current medical interventions.

Purpose of the Study:

To provide a comprehensive overview of skeletal organoid technology.
To systematically review advancements in the construction and application of bone, muscle, and joint organoids.
To explore future opportunities and challenges in skeletal organoid research for personalized and regenerative medicine.

Main Methods:

Review of existing literature on organoid technology and skeletal biology.
Systematic summarization of progress in skeletal organoid development.
Analysis of the application potential of skeletal organoids in disease modeling and regenerative medicine.

Main Results:

Organoid technology provides a 3D in vitro model that mimics native tissue structure and function.
Significant progress has been made in developing bone, muscle, and joint organoids.
Skeletal organoids show broad potential for drug screening, disease mechanism studies, and tissue regeneration.

Conclusions:

Skeletal organoids represent a powerful tool for advancing understanding and treatment of musculoskeletal disorders.
Further research into skeletal organoids is essential for unlocking their full potential in personalized and regenerative medicine.
This review offers valuable insights and references for researchers in the field of skeletal organoids.