Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity

Area of Science:

• Biomaterials Science
• Dental Materials Science
• Nanotechnology in Dentistry

Background:

• Dentin hypersensitivity and fluid leakage are significant clinical concerns.
• Developing materials that can occlude dentinal tubules is crucial for reducing permeability.
• Nanosized silicates offer potential for forming effective intratubular plugs.

Purpose of the Study:

• To assess the intratubular crystal formation of dicalcium silicate (DCS) and tricalcium silicate (TCS) nanoparticles.
• To evaluate the impact of these materials on dentin permeability reduction.
• To determine the acid resistance of the formed crystals.

Main Methods:

• Extracted premolars were treated with DCS/TCS or TCS experimental materials.
• Specimens were stored in phosphate-buffered saline (PBS) for up to 90 days.
• Dentin hydraulic conductance (Lp) was measured before and after an acid challenge.

Main Results:

• Experimental materials formed hydroxyapatite-like crystals with a similar Ca/P ratio.
• Intratubular crystal formation led to a gradual decrease in dentin permeability over time.
• The formed crystals demonstrated resistance to a 1M acetic acid challenge.

Conclusions:

• Nanosized DCS and TCS materials effectively form acid-resistant intratubular crystals.
• These crystals significantly reduce dentin permeability.
• The findings suggest potential for these materials in managing dentin hypersensitivity.