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Impulse control in Parkinson's disease: Distinct effects between action and choice.
Aliya C M Warden1, Craig McAllister1, Marit F L Ruitenberg2
1School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Neuroscience and Biobehavioral Reviews
|January 28, 2025
Summary
Impulse control issues in Parkinson's disease (PD) differ between actions and choices. Impulsive actions appear early, while choice impairments may emerge with medication, highlighting distinct progression patterns.
Area of Science:
- Neuroscience
- Neurology
- Behavioral Science
Background:
- Parkinson's disease (PD) presents with motor symptoms and non-motor issues, including impulse control deficits.
- Existing research often examines impulsive action and impulsive choice separately, limiting a full understanding of impaired impulse control in PD.
Purpose of the Study:
- To review and integrate findings on impulsive action and impulsive choice in Parkinson's disease.
- To explore the influence of dopaminergic medication and disease progression on these distinct impulsivity domains.
Main Methods:
- Qualitative review of behavioral studies assessing impulsive action and choice in Parkinson's disease samples.
- Analysis of findings considering medication status (on/off dopaminergic medication) and disease stage.
Main Results:
- A distinction exists between impulsive action and impulsive choice in PD.
- Impulsive action deficits are evident in early, non-medicated PD and persist.
- Impulsive choice impairments may be associated with dopaminergic medication, with limited data in non-medicated individuals.
Conclusions:
- Impulse control in Parkinson's disease involves distinct trajectories for action and choice.
- Further research is needed, particularly longitudinal studies, to clarify the impact of medication and disease progression.
- Future studies should integrate both impulsive action and choice tasks within the same Parkinson's disease samples.
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